Dr. Alfred W. Pennington, who in the 1940s got 20 obese DuPont employees to lose an average 22 pounds in 14 weeks on a calorically unrestricted low-carb diet. This concept of lowering carbs goes all the way back to the mid-nineteenth century when William Banting, a well-known, and obese, undertaker at the time, changed his diet based on the recommendation of his doctor and lost weight; he wrote and published Letter on Corpulence describing his experience with the low-carb diet.
In 1961, Dr. Hermann Taller published a book, Calories Don’t Count, that promoted a low-carb diet. It sold two million copies, despite the fact that Dr. Taller was charged with fraud by the FDA, for using the book to push sales of his proprietary safflower pills.