Babe Ruth and the New York Yankees won the 1932 World Series. Afterwards, Ruth and three others, went to Springfield Illinois to do some fishing. As they were returning, Ruth and friends, gave out souvenirs up and down the road know as, 'The Mother Road', Route 66.
After 90 years, autographed baseballs from that trip start becoming targets with arson, theft, and murder. State Police detectives, Beth and Joe Clayton are tasked with finding out who is behind the crimes. The pair were put together as husband and wife to better protect their identity. Their relationship is tenuous at as Beth is constantly annoyed with her new husband. Joe's juvenile humor only hurts his attempt to win the heart of his new wife. Joe Clayton is still struggling to get over the murder of his first wife.
During the search, they come across an unusual cast of characters. They include, Susie Quantrill, a TV reporter who believes she is jinxed. Weatherman Doug Willkie, who has a long time crush on a co-worker and a roommate who has taken over his life. A police techie, known only as Blazer, who has a weird diet but skills as a hacker. Trooper Aretha 'Ree' Franklin helps as Beth's only friend. They find unusual relationships at a trailer park and a TV station. There is a young man who believes he is related to a civil war general and a nurse who enjoys doing first aid in the nude. Does the man with a stolen identity figure in the crimes.
As the historic Mother Road is fading away, the Claytons travel up and down the old road, looking for answers.
